GPP2021
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Kurzvorträge 3 - Asthma Forschung

   
Shortcut: KV-03
Raum: Live Slot 5
Sessiontyp: Vortrag/Poster

 

Abstract

KV-03-01

Der proresolvine Lipidmediator Lipoxin A4 korreliert negativ mit proinflammatorischen Chemokinen und charakterisiert eine Subgruppe von Asthmapatienten (#113)

I. Ricklefs1, L. Schäfer1, N. Weissheimer1, M. Weckmann1, D. Thiele2, I. R. König2, E. von Mutius3, G. Hansen4, K. F. Rabe5, M. V. Kopp1

1 Universität zu Lübeck, UKSH, Sektion Pädiatrische Pneumologie & Allergologie, Airway Research Center North (ARCN), Mitglied des Deutschen Zentrums für Lungenforschung (DZL), Lübeck, Schleswig-Holstein, Deutschland
2 Universität zu Lübeck, UKSH, Institut für Medizinische Biometrie und Statistik, Lübeck, Schleswig-Holstein, Deutschland
3 Ludwig Maximilian Universität München, Pädiatrische Pneumologie und Allergologie, Comprehensive Pneumology Center Munich (CPC-M), Mitglied des DZL, München, Bayern, Deutschland
4 Medizinische Hochschule Hannover (MHH), Klinik für Pädiatrische Pneumologie, Allergologie und Neonatologie, Biomedical Research in End-stage and Obstructive Lung Disease Hannover (BREATH), Mitglied des DZL, Hannover, Niedersachsen, Deutschland
5 LungenClinic Grosshansdorf, Akademisches Lehrkrankenhaus der Universität zu Lübeck, Abteilung für Pneumologie, Großhansdorf, Schleswig-Holstein, Deutschland

Stichwörter: Asthma, Biomarker, Resolution
KV-03-02

Mepolizumab–Therapie einer 8 jährigen Patientin mit CF und schwerem eosinophilem Asthma bronchiale (#95)

A. Wesner1, F. Reeß1, J. Freihorst1, M. A. Rose1

1 Klinikum Stuttgart, Pädiatrie 3, Stuttgart, Deutschland

Stichwörter: Asthma bronchiale, Eosinophiles Asthma bronchiale, Biologika-Therapie, Mepolizumab
KV-03-03

Tumstatin Degradation Product C4MA3 In The Serum Of Preschool Children – An Early Predictor Of Asthma In Later Childhood And Adolescence? (#1)

N. Maison1, 5, J. M. Bülow Sand2, S. Rank Rønnow2, D. J. Leeming2, B. Schaub1, 5, M. Ege1, 5, R. Grychtol3, 8, A. - M. Dittrich3, 8, K. F. Rabe6, 7, E. von Mutius1, 5, M. V. Kopp4, 7, G. Hansen3, 8, A. Hose1, 5, T. Bahmer6, 7, M. Weckmann4, 7

1 Ludwig-Maximilians-Universität, Dr. von Hauner Children’s Hospital, Department of Allergy, Munich, Germany
2 Nordic Bioscience, Herlev, Denmark
3 Hannover Medical School, Children’s Hospital, Dept. for Ped. Pneumology, Allergy und Neonatology, Hannover, Germany
4 University of Lübeck, Children’s Hospital, Division of Pediatric Pulmonology and Allergology, Luebeck, Germany
5 Comprehensive Pneumology Center - Munich (CPC-M), German Center for Lung Research (DZL), Munich, Germany
6 LungenClinic Grosshansdorf, Großhansdorf, Germany
7 Airway Research Center North (ARCN), German Center for Lung Research (DZL), Großhansdorf, Germany
8 Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover, Germany

Stichwörter: Remodelling, Asthma, predictor, tumstatin
KV-03-04

COL4A3 degradation predicts anti-IgE response in severe asthma (#11)

M. Weckmann1, T. Bahmer2, 3, J. M. Bülow Sand4, S. Rank Rønnow4, 5, D. J. Leeming4, M. A. Karsdal4, L. Lunding6, M. Wegmann6, B. G. Oliver7, 8, G. Ulrich-Merzenich9, U. Juergens10, J. Duhn11, Y. Laumonnier11, O. Danov12, K. Sewald12, U. M. Zissler13, M. Jonker14, I. R. König16, G. Hansen17, E. von Mutius18, O. Fuchs19, 1, A. - M. Dittrich17, B. Schaub18, C. Happle17, K. F. Rabe2, M. van de Berge14, J. K. Burgess8, 15, 20, M. V. Kopp1, ALLIANCE Study Group as part of the German Centre for Lung Research

1 Division of Pediatric Pneumology & Allergology, University Medical Center Schleswig-Holstein, Lübeck, Germany; Airway Research Center North (ARCN), Member of the German Center for Lung Research (DZL), Germany, Lübeck, Deutschland
2 Department of Pneumology, LungenClinic Grosshansdorf, Grosshansdorf, Germany; Airway Research Center North (ARCN), Member of the German Center for Lung Research (DZL), Germany, Grosshansdorf, Deutschland
3 University Hospital Schleswig-Holstein Campus Kiel, Department for Internal Medicine I, Kiel, Germany, Airway Research Center North (ARCN), German Center for Lung Research (DZL), Kiel, Deutschland
4 Nordic Bioscience A/S, Herlev, Denmark, Herlev, Dänemark
5 University of Southern Denmark, The Faculty of Health Science, Odense, Denmark, Odense, Dänemark
6 Division of Asthma-Exacerbation & -Regulation; Program Area Asthma & Allergy, Leibniz-Center for Medicine and Biosciences Borstel; Airway Research Center North (ARCN), Member of the German Center for Lung Research (DZL), Germany, Borstel, Deutschland
7 School of Medical and Molecular Biosciences, University of Technology Sydney NSW 2007 Australia, Sydney, Australien
8 Woolcock Institute of Medical Research, The University of Sydney, Glebe, NSW, Australia, Glebe, Deutschland
9 AG Synergyresearch and Experimental Medicine, Medical Clinic III, University Hospital Bonn, Bonn, Deutschland
10 Department of Pneumonology, Medical Clinic II, University Hospital Bonn, Bonn, Deutschland
11 Institute for Systemic Inflammation Research, University of Lübeck, Lübeck 23562, Germany, Lübeck, Deutschland
12 Fraunhofer Institute for Toxicology and Experimental Medicine ITEM, Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Nikolai-Fuchs-Strasse 1, 30625 Hannover, Germany, Hannover, Deutschland
13 Center of Allergy and Environment (ZAUM), Technical University of Munich and Helmholtz Center Munich, German Research Center for Environmental Health (CPC-M), Munich, Member of the German Center of Lung Research (DZL), Germany, München, Deutschland
14 University of Groningen, University Medical Center Groningen, Department of Pulmonary Diseases, Groningen, GRIAC (Groningen Research Institute for Asthma and COPD), The Netherlands, Groningen, Niederlande
15 University of Groningen, University Medical Center Groningen, Department of Pathology & Medical Biology, Groningen, GRIAC (Groningen Research Institute for Asthma and COPD), The Netherlands, Groningen, Niederlande
16 Institute for Medical Biometry and Statistics, University of Lübeck, Lübeck, Germany; Airway Research Center North (ARCN), Member of the German Center for Lung Research (DZL), Germany, Lübeck, Deutschland
17 Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center of Lung Research (DZL), Germany, Hannover, Deutschland
18 University Children’s Hospital, Ludwig Maximilian’s University, Munich, Germany; German Research Center for Environmental Health (CPC-M), Munich, Germany, Member of the German Center of Lung Research (DZL), München, Deutschland
19 Department of Paediatric Respiratory Medicine, Inselspital, University Children's Hospital of Bern, University of Bern, Bern, Switzerland, Bern, Schweiz
20 Discipline of Pharmacology, Faculty of Medicine, The University of Sydney, NSW, Australia, Sydney, Australien

Stichwörter: Omalizumab, Asthma, Biomarker, Kollagen
KV-03-05

Neutrophil granulocytes from Th1-high asthmatics migrate faster towards bacterial compound ex vivo (#13)

S. Lemmel1, T. Becker1, 2, A. Wohlers1, A. Bachmann1, T. Bahmer3, 4, G. Hansen5, E. von Mutius6, K. F. Rabe4, O. Fuchs7, 1, A. - M. Dittrich5, B. Schaub6, C. Happle5, M. Weckmann1, M. V. Kopp1, A. .. ALLIANCE Study Group as part of the German Centre for Lung Research1

1 Department of Paediatric Pneumology & Allergology, University Children's Hospital, Schleswig-Holstein, Campus Lübeck, Airway Research Center North (ARCN), Member of the German Center for Lung Research, Lübeck, Germany
2 Imaging Platform, Broad Institute of MIT and Harvard,, Cambridge, United States of America
3 Department of Pneumology, LungenClinic Grosshansdorf, Grosshansdorf, Germany; Airway Research Center North (ARCN), Member of the German Center for Lung Research, Grosshansdorf, Germany
4 Department of Pneumology, LungenClinic Grosshansdorf, Grosshansdorf, Germany; Airway Research Center North (ARCN), Member of the German Center for Lung Research (DZL), Kiel, Germany
5 Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center of Lung Research, Hannover, Germany
6 University Children’s Hospital, Ludwig Maximilian’s University, Munich, Germany; German Research Center for Environmental Health (CPC-M), Munich, Germany, Member of the German Center of Lung Research, München, Germany
7 Department of Paediatric Respiratory Medicine, Inselspital, University Children's Hospital of Bern, University of Bern, Bern, Bern, Switzerland

Stichwörter: Asthma, Phenotype, Neutrophil, Migration
KV-03-06

Tiotropium ist eine neue Behandlungsoption für schweres, unkontrolliertes Asthma im Vorschulalter (#36)

G. Reichert1, H. Donath1, J. Trischler1, M. Eckrich2, J. Schulze1, K. Blümchen1, S. Zielen1

1 Universitärsklinikum Frankfurt, Allergologie, Pneumologie und Mukoviszidose, Klinik für Kinder- und Jugendmedizin, Universitätsklinikum Frankfurt, Frankfurt, Deutschland
2 Kinderarztpraxis Eckrich, Offenbach, Deutschland

Stichwörter: Asthma, Thiotropium, neue Therapieoptionen, Asthmakontrolle, Vorschulalter
KV-03-07

Unzureichende Asthma ICD Kodierung bei akuter Dyspnoe und Hospitalisierung im Vorschulalter (#38)

V. Wiersig1, S. Kluge1, H. Donath1, J. Trischler1, J. Schulze1, K. Blümchen1, S. Zielen1

1 Universitätsklinikum Frankfurt, Allergologie, Pneumologie und Mukoviszidose, Klinik für Kinder- und Jugendmedizin, Frankfurt, Hessen, Deutschland

Stichwörter: Hospitalisierung, Dyspnoe, Vorschulkinder, Asthma, Atemnot
KV-03-08

Asthma Phänotypisierung und Re-Hospitalisierungsraten bei stationär behandelten Vorschulkindern mit akutem, schwerem Asthma (#39)

S. Kluge1, V. Wiersig1, J. Trischler1, H. Donath1, J. Schulze1, K. Blümchen1, S. Zielen1

1 Universitätsklinikum Frankfurt, Allergologie, Pneumologie und Mukoviszidose, Klinik für Kinder- und Jugendmedizin, Frankfurt, Hessen, Deutschland

Stichwörter: Asthma, Vorschulkinder, Rehospitalisierung, Phänotypisierung, Therapie
KV-03-09

MRI Imaging in pediatric patients with recurrent wheeze and asthma – a pilot study (#54)

N. Maison1, 2, M. Schneider3, 2, D. Bondesson1, 2, B. Schaub1, 2, K. F. Rabe4, 6, M. V. Kopp5, 6, G. Hansen7, 8, T. Bahmer4, 6, E. von Mutius1, 2, J. Dinkel3, 2

1 Ludwig-Maximilian-Universität, Department of Allergy, Dr. von Hauner Children's Hospital, Munich, Germany
2 German Center for Lung Research (DZL), Comprehensive Pneumology Center - Munich (CPC-M), Munich, Germany
3 Ludwig-Maximilians-Universität München, Department of Radiology, Munich, Germany
4 LungenClinic Grosshansdorf, Großhansdorf, Germany
5 University of Luebeck, Children’s Hospital, Division of Pediatric Pulmonology and Allergology, Luebeck, Germany
6 German Center for Lung Research (DZL), Airway Research Center North (ARCN), Großhansdorf, Germany
7 Hannover Medical School, Dept. For Ped. Pneumology, Allergy und Neonatology, Hannover, Germany
8 German Center for Lung Research (DZL), Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Hannover, Germany

Stichwörter: MRI, Asthma, obstruction, imaging
KV-03-10

Effect of Air Pollution and Greenness on the Nasal Microbiota in Infancy (#121)

A. Gisler1, 2, I. Korten2, M. Hilty3, 4, K. de Hoogh5, 6, D. Vienneau5, 6, U. Frey1, F. Decrue1, O. Gorlanova1, A. Soti2, P. Latzin2, J. Usemann1, 2, 7

1 University Children's Hospital Basel (UKBB), Pediatric Pulmonology Research, Basel, Basel-Stadt, Switzerland
2 Inselspital, Pediatric Respiratory Medicine, Bern, Bern, Switzerland
3 University of Bern, Institute for Infectious Diseases, Bern, Bern, Switzerland
4 Inselspital, Department of Infectious Diseases, Bern, Bern, Switzerland
5 Swiss Tropical and Public Health Institute, Basel, Basel-Stadt, Switzerland
6 University of Basel, Basel, Basel-Stadt, Switzerland
7 University Children's Hospital Zurich, Division of Respiratory Medicine, Zürich, Zürich, Switzerland

Stichwörter: NDVI, Particulate matter, Microbiota, Longitudinal studies, Infant